Wondering about the best wager among all 16 NFL games in Week 1? Our pick, in terms of the point spreads, is Vikings -1.5. But continue reading, because we have plenty more suggestions, and that could lead to parlay opportunities.

Best Week 1 Spread Bets

Jump to Matchup:

Pick: Vikings -1.5 vs. Giants

• Matchup: Minnesota Vikings at New York Giants
• Projected Winner & Margin: Vikings by 3.7 points (Bet on this game at BetMGM)
• Spread: Vikings -1.5
• Time: 1:00 PM ET
• Date: September 8
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Packers +2.5 vs. Eagles

• Matchup: Green Bay Packers at Philadelphia Eagles
• Projected Winner & Margin: Packers by 3.8 points (Bet on this game at BetMGM)
• Spread: Eagles -2.5
• Time: 8:15 PM ET
• Date: September 6
• TV Channel: Peacock
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Cowboys +2.5 vs. Browns

• Matchup: Dallas Cowboys at Cleveland Browns
• Projected Winner & Margin: Cowboys by 0.6 points (Bet on this game at BetMGM)
• Spread: Browns -2.5
• Time: 4:25 PM ET
• Date: September 8
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Ravens +3 vs. Chiefs

• Matchup: Baltimore Ravens at Kansas City Chiefs
• Projected Winner & Margin: Ravens by 3.9 points (Bet on this game at BetMGM)
• Spread: Chiefs -3
• Time: 8:20 PM ET
• Date: September 5
• TV Channel: NBC
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Colts +3 vs. Texans

• Matchup: Houston Texans at Indianapolis Colts
• Projected Winner & Margin: Colts by 0.1 points (Bet on this game at BetMGM)
• Spread: Texans -3
• Time: 1:00 PM ET
• Date: September 8
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Make smart decisions. Use those stats when making your NFL picks and place your bet on BetMGM.

Best Week 1 Total Bets

Jump to Matchup:

Under 47 – Ravens vs. Chiefs

• Matchup: Baltimore Ravens at Kansas City Chiefs
• Projected Total: 40.4 points (Bet on this game at BetMGM)
• Time: 8:20 PM ET
• Date: September 5
• TV Channel: NBC
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Over 41.5 – Cowboys vs. Browns

• Matchup: Dallas Cowboys at Cleveland Browns
• Projected Total: 47.8 points (Bet on this game at BetMGM)
• Time: 4:25 PM ET
• Date: September 8
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Under 51 – Rams vs. Lions

• Matchup: Los Angeles Rams at Detroit Lions
• Projected Total: 48.6 points (Bet on this game at BetMGM)
• Time: 8:20 PM ET
• Date: September 8
• TV Channel: NBC
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Under 49 – Jaguars vs. Dolphins

• Matchup: Jacksonville Jaguars at Miami Dolphins
• Projected Total: 47.6 points (Bet on this game at BetMGM)
• Time: 1:00 PM ET
• Date: September 8
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Under 44 – Jets vs. 49ers

• Matchup: New York Jets at San Francisco 49ers
• Projected Total: 40.8 points (Bet on this game at BetMGM)
• Time: 8:15 PM ET
• Date: September 9
• TV Channel: ABC/ESPN
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Catch every NFL touchdown with NFL RedZone on Fubo.

Not all offers available in all states, please visit BetMGM for the latest promotions for your area. Must be 21+ to gamble, please wager responsibly. If you or someone you know has a gambling problem, contact 1-800-GAMBLER.