BEIRUT (AP) — World leaders rallied around the United States after it launched a missile strike early Friday on a Syrian air base in response to this week’s chemical attack, while Russia condemned the move as “aggression” and suspended crucial coordination with Washington in Syria’s congested skies.

The overnight missile attack, which marked the first time the U.S. has directly targeted Syrian President Bashar Assad’s forces, was condemned by his allies in Russia and Iran but welcomed by the Syrian opposition and its supporters, who expressed hope it signaled a turning point in the devastating six-year-old civil war.

The bombing represents Trump’s most dramatic military order since taking office and thrusts the U.S. administration deeper into the complex Syrian conflict. The Obama administration threatened to attack Assad’s forces after previous chemical attacks, but never followed through. Trump called on “all civilized nations” to join the U.S. in seeking an end to the carnage in Syria.

About 60 U.S. Tomahawk missiles hit the Shayrat air base, southeast of Homs, a small installation with two runways, where aircraft often take off to bomb targets in northern and central Syria. The U.S. missiles hit at 3:45 a.m. Friday morning and targeted the base’s airstrips, hangars, control tower and ammunition areas, U.S. officials said.

They were fired from two warships in the Mediterranean Sea, in retaliation for Tuesday’s deadly chemical attack, which officials said used chlorine mixed with a nerve agent, possibly sarin.

The Kremlin said President Vladimir Putin believes the U.S. strike is an “aggression against a sovereign state in violation of international law.” Spokesman Dmitry Peskov said Putin believes the U.S. launched the strikes under a “far-fetched pretext.”

“Washington’s move deals a significant blow to the Russia-U.S. relations, which are already in a deplorable shape,” Peskov said.