Holloway grabbed the ball from Blue Demons forward Cleveland Melvin and dashed downcourt for the score.
Holloway had 16 points and 12 rebounds for the Rebels (6-1), who led by 17 points early in the second half. It was Holloway’s third double-double of the season and the 17th of his career.
Brandon Young had 18 points for DePaul (4-2), and Melvin added 14 points and 10 rebounds.
The victory was the first road win over a Big East opponent in Ole Miss history. It marked the third straight win for Ole Miss and second in three meetings against the Blue Demons.
The Rebels built a double-digit lead while DePaul failed to make a field goal in the final 7:04 of the first half.
Nick Williams led the Rebels with a season-high 17 points on 7 of 9 shooting. (December 2, 2011, Page 6A)